Schizophrenia is a chronic, severe mental health condition thought to result from some combination of genetic and environmental factors. Imbalances in brain chemicals, such as dopamine and glutamate, also seem to play a role in schizophrenia.

Schizophrenia is diagnosed both by “positive” symptoms—among them hallucinations, delusions, and other disordered thinking—as well as “negative” symptoms such as reduced expression of emotion and speaking less. People who have this condition also may experience difficulties with cognitive functions such as decision making, planning, paying attention, and working memory.

There has been a great deal of talk about the role of gut flora, also known as the “microbiome,” and mental health. It may sound surprising, but severity of symptoms in depression, anxiety, autism, and now schizophrenia have been linked to imbalances in the gastrointestinal (GI) tract. More recent research has suggested a relationship between activity of the immune system, increased inflammation, the presence of food sensitivities, and imbalances in the GI tract in the presentation of schizophrenia.

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What’s the Gut Got to Do with It?

During the normal birth process, our GI tracts are populated with “good” bacteria (by moving down the mother’s vaginal canal). This, our diets, stress levels, and other factors subsequently affect our gut bacteria and our overall health, as well as our brain development.

Gut bacteria help regulate proteins and other substances that influence the brain’s development. One substance, “brain-derived neurotrophic factor” or BDNF, impacts the brain’s ability to develop new neurons and remain adaptable (referred to as neuroplasticity).

Our gut environment also appears to affect receptors in our brains. Receptors may be thought of as the equivalent of a keyhole on the surface of a neuron. Brain chemicals are like the “keys” that are designed to fit in a specific type of receptor. Once such type of receptor, the NMDA, is a type of glutamate receptor involved in, among other things, plasticity (or adaptability) of neurons related to memory and other functions. An unbalanced microbiome (gut bacteria, or flora) can lead to under-functioning NMDA receptors and variations in BDNF that may contribute to the production of schizophrenia symptoms.

Structural damage to the GI tract in people with schizophrenia has been linked to developing antibodies to brain cells in the hippocampus, amygdala, and frontal cortex. These brain areas are involved in working memory, emotion, motivation, decision making, and logical thinking—all of which may be impaired in people with schizophrenia.

Dr. Kaitlyn Nemani and colleagues reviewed the literature on the role of the gut in schizophrenia. Their review found that imbalances in the microbiome may be linked to structural damage in the gut, inflammation, and the development of autoimmune disorders. People who have schizophrenia, as well as their relatives, have been found to have a greater incidence of autoimmune disorders than people who either do not have or are not related to someone with schizophrenia.

In addition, structural damage to the GI tract in people with schizophrenia has been linked to developing antibodies to brain cells in the hippocampus, amygdala, and prefrontal cortex. These brain areas are involved in working memory, emotion, motivation, decision making, and logical thinking—all of which may be impaired in people with schizophrenia.

Gut flora imbalances may also play a role in increased sensitivity to gluten (a protein found in grains) and casein, which is the main protein found in milk and milk products. A growing body of research has found a relationship between gluten sensitivity that is not due to celiac disease and symptoms of both schizophrenia and autism.

Finally, imbalances in gut flora are linked to obesity and insulin resistance, both of which are linked to diabetes. People who have schizophrenia have an increased risk for these types of metabolic imbalances, and antipsychotic medication can further induce weight gain that can lead to metabolic problems and diabetes.

Novel Therapies to Balance the Gut

Dr. Nemani and colleagues suggest some nontraditional therapies that may complement existing medication and psychotherapy approaches for treating schizophrenia. These include:

1. Dietary changes. Although the evidence has been mixed, there is some data and also anecdotal reports suggesting that a subset of people who have schizophrenia benefit from avoiding gluten-containing foods (i.e., wheat, rye, barley, and other grains). Data regarding the impact of a casein-free diet on schizophrenia symptoms are lacking, but if your current treatment regimen provides insufficient relief, or you have GI symptoms that appear to worsen after consuming dairy, it may be worth going dairy-free for a few weeks to see if this improves your symptoms.
2. Antimicrobials. Minocycline (a form of tetracycline) is under investigation as an adjunct treatment in people with schizophrenia. It is thought to reduce inflammation and enhance glutamate neurotransmission.
3. Probiotics. Probiotics, or supplements containing “good bacteria,” may help balance gut flora and have been shown to positively impact mood, digestion, immunity, and weight. There does not appear to be risk associated with taking probiotics.

The last type of novel therapy discussed by the authors is fecal transplantation, or transplanting the fecal bacteria from someone with a healthy microbiome to a person who has a gut imbalance. Although this is considered a cutting-edge GI treatment for those who have inflammatory bowel disease, the authors conclude that a better understanding of the microbiome in those with schizophrenia is needed to know if this therapy is warranted.

As always, consult with your medical team when considering new therapies, conventional or complementary, such as those described above.

References:

1. Celiac Disease Foundation. (n.d.). Sources of Gluten. Retrieved from https://celiac.org/live-gluten-free/glutenfreediet/sources-of-gluten/
2. National Institute of Mental Health. (2016). Schizophrenia. Retrieved from http://www.nimh.nih.gov/health/topics/schizophrenia/index.shtml
3. Nemani, K., Ghomi, R. H., McCormick, B., & Fan, X. (2015). Schizophrenia and the gut-brain axis. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 56, 155-160.

Most women have experienced some symptom of premenstrual discomfort at one point or another—whether it be bloating, aches and pains, breast tenderness, fatigue, tension, headaches, or sleep, eating, and/or mood disturbances. By some estimates, up to 80% of women experience at least one symptom with some regularity. For approximately 5% of women, however, symptoms are severe enough to meet criteria for premenstrual dysphoric disorder, or PMDD.

PMDD can lead to impaired functioning and quality of life during the last week of the menstrual cycle and until about 4 days after menstruation has begun. Significant anxiety, depression, and irritability are commonly reported features of PMDD. Women with either premenstrual syndrome (PMS) or PMDD frequently seek relief in one or a combination of over-the-counter medications, a prescription, or natural remedies, but too often relief is elusive.

What Causes PMS and PMDD?

Although at present there is no definitive understanding of why some develop these syndromes and others do not, a woman’s body undergoes a number of hormonal changes throughout her cycle. It is thought that disruptions in these processes may lead to the above symptoms. Specifically, disruptions in the hormone progesterone as well as in neurotransmitters (chemicals in the brain), such as serotonin and gamma-aminobutyric acid (GABA), and the stress hormone cortisol, may be responsible for PMS or PMDD.

There has also been research examining the roles of calcium and magnesium in these conditions because both minerals vary with the menstrual cycle; however, it is not entirely clear whether imbalances in calcium and magnesium directly cause PMS/PMDD. Although there is not enough data to establish a causal relationship, being sedentary, consuming large amounts of caffeine, sugar, and alcohol, and being very stressed are among the factors associated with having PMS.

Mental, Physical, or Both?

Many women with PMDD also meet criteria for major depressive disorder or seasonal affective disorder, and some have panic or other symptoms of anxiety that are quite severe. It is important to note that although PMDD is included in the Diagnostic and Statistical Manual of Mental Disorders, it is a condition that has a physiologic basis, even though it may include psychiatric symptoms or coexist with other psychiatric disorders.

[fat_widget_left]What’s a Woman to Do?

There are a number of natural remedies that are commonly used for PMS or PMDD symptoms, including chasteberry (also known as Vitex or Monk’s Pepper), evening primrose oil, saffron, St. John’s wort, soy, B6, calcium, and magnesium. Only a few of these remedies have sufficient evidence to support their use at this time, however. These include:

• Calcium – 1,000 to 1,200 mg per day (effective for mood, water retention, food cravings, and pain)
• Vitamin B6 – 100 mg per day (preliminary evidence suggest benefit for relieving mood symptoms)
• Chasteberry – 20 mg per day (preliminary evidence suggests benefits for relieving breast tenderness, headaches, and irritability). Note that in some trials, chasteberry increased the likelihood of becoming pregnant, so make sure to use adequate birth control when taking this herb, and discontinue use if you become pregnant.

Discuss any herbal or vitamin supplements you take with your doctor to make sure these are appropriate for you and that they will not interfere with other supplements or medications you may be taking.

In addition to the above, the following lifestyle changes are recommended:

• Get regular exercise (aim for most days of the week, for at least 30 minutes per day)
• Decrease or eliminate caffeine, alcohol, and sugar
• Engage in active stress management such as meditation, guided imagery, yoga, and involvement in pleasurable activities
• Talk therapy, especially cognitive behavioral therapy, can help you identify triggers of low mood and develop strategies to cope with symptoms when they arise

It goes without saying that if you have premenstrual symptoms that make it hard to do the things you want and need to do, see your gynecologist for an accurate diagnosis. He/she can help rule out other physical or psychological syndromes that may appear similar to PMS or PMDD. If your mood symptoms are severe (e.g., you experience panic or disabling anxiety, feelings of hopelessness, or suicidal thoughts), seek professional help immediately.

For more information, consult the following:

• Mayo Clinic’s page premenstrual syndrome (PMS)
• Discovery Health’s Menstrual Disorders section

References

1. Pearlstein, T., & Steiner, M. (2008). Premenstrual dysphoric disorder: burden of illness and treatment update. Journal of Psychiatry & Neuroscience, 33(4): 291–301.
2. Whelan, A. M., Jurgens, T. M., & Naylor, H. (2009). Herbs, vitamins, and minerals in the treatment of premenstrual syndrome: a systematic review. Canadian Journal of Clinical Pharmacology, 16(3), e430-e431.

Everyone seems to be talking about the Bs lately. Specifically, B12 and folic acid (or folate) are making headlines for their roles in mental health and illness. Both of these vitamins play an essential role in a number of key bodily processes.

Symptoms of a Deficiency

A deficiency in B12 or folate may take months or years to become evident, and may lead to symptoms such as fatigue, muscle weakness, diarrhea, difficulty concentrating, forgetfulness, sleeplessness, irritability, and mood swings. In more severe cases, deficiency can result in seizures, dementia, or parathesia (burning, prickling, tingling, numbness, or a crawling sensation in the extremities or elsewhere in the body).

Low levels of B12 and folate are associated with having higher levels of homocysteine, an amino acid found in the blood; when levels are too high, the risk of cardiovascular disease and cognitive problems increase. What is particularly interesting about this relationship is that over the past several years, more research has emerged showing a link between depression, and to lesser extents, anxiety, hostility, and increased likelihood of cardiovascular problems. Additionally, people who have heart disease have higher rates of depression than what is seen in the general population. It is unclear if the sole or definitive link between heart disease and B-vitamins is homocysteine levels, but the relationship is intriguing.

Who is at Risk?

Risk factors for B12 or folate deficiencies include following a vegan diet ( B12 is only found in animal products), being elderly, having an inflammatory bowel disease, being malnourished, having liver problems, being pregnant, using proton pump inhibitors regularly (medications that reduce stomach acid), and alcoholism. In addition, certain medications may interfere with the absorption of B12 or folate.

What’s the Evidence?

Recent research has investigated whether supplementation with B12 or folate could yield observable improvements in cognitive functioning or mood. A 2012 study examined the effects of supplementation on cognitive functioning in 700 elderly adults who had symptoms of depression but did not meet full criteria for a depressive disorder. Improvements in some aspects of memory (immediate and delayed recall) were significant, if not modest, but were only seen after two years of daily use. Supplementation did result in significantly higher blood levels of B12 and folate, and significantly lower increases in levels of homocysteine over time, as compared to taking a placebo.

Other research has found that approximately one third of depressed patients have low levels of folate and elevated levels of homocysteine. Treatment with antidepressants may be less effective in those with low levels of B12. Adequate levels of folate and B12 are also important for those taking the supplement SAM-e (S-adenosyl-methionine). SAM-e is a popular over-the-counter supplement typically used to treat depressive symptoms or pain due to osteoarthritis or fibromyalgia. SAM-e is sometimes used in conjunction with conventional antidepressants to boost their effectiveness in those who don’t respond sufficiently to antidepressants alone.

Finally, a 2010 paper discussed two case reports in which depressed patients had failed to respond to three different trials of antidepressant therapies. In each case, the patient was a male vegetarian with low levels of B12. One of the men had sleep difficulties that progressed to complete insomnia, as well as cognitive symptoms (slowness in thinking, difficulty performing calculations, and forgetting names of objects and people). The other experienced problems with attention-concentration, learning new information, and immediate and visual recall of information. In both cases, supplementation resulted in an improved response to medication and reduction in depressive, sleep, and other cognitive symptoms.

Although recent headlines and some of the study findings suggest a link, it is important to note that more research needs to be done to definitively state whether B-vitamin supplementation can reduce, prevent, or reverse cognitive or mood problems in healthy or ill people.

Recommendations

• Strive for a healthy diet comprised of adequate amounts of high-quality food. This should include whole grains, vegetables and fruits, beans/legumes, as well as fish, dairy, and other lean proteins if you eat animal foods.
• B12 and folic acid supplements are water soluble and tend to be safe in moderate doses. If you do choose to take supplements, be aware that when taken without B12, folate can mask a B12 deficiency. Thus, it is typically recommended to add B12 if you are already taking a folic acid supplement.
• If you fall into one or more of the higher-risk categories mentioned above, it is worth consulting with your physician and/or a registered dietician regarding whether supplementation is warranted or to adjust your diet appropriately.
• If you have any of the cognitive, psychological, or physical symptoms mentioned above, consult a health care provider immediately.
• Learn more about dietary supplements at the National Institutes of Health’s Office of Dietary Supplement’s page

References:

1. Kate, N, Grover, S, and Agarwal, M. (2010). Does B12 deficiency lead to lack of treatment response to conventional antidepressants? Psychiatry, 7(11), 42-44.
2. Stanger O, Fowler B, Piertzik K, Huemer M, Haschke-Becher E, Semmler A, Lorenzl S, & Linnebank M (2009). Homocysteine, folate and vitamin B12 in neuropsychiatric diseases: review and treatment recommendations. Expert Rev Neurother, 9(9), 1393-412.
3. Walker, JG, Batterham, PJ, Mackinnon, AJ, Jorm, AF, Hickie, I, Fenech, M, et al. (2012). Oral folic acid and vitamin B-12 supplementation to prevent cognitive decline in community-dwelling older adults with depressive symptoms—the Beyond Ageing Project: a randomized controlled trial.  American Journal of Clinical Nutrition, 95(1), 194-203.

Scents, Memories, and Emotions

The use of pleasant aromas to enhance well-being dates back thousands of years. Fragrant oils were ceremonially used in the Far East, as well as in ancient Egypt and Greece. Essential oils were extracted from herbs and flowers to create medicines and perfumes, to scent one’s home, and to anoint the ill and deceased.

Smell is considered to be the most poorly understood of our senses, yet most have experienced the powerful ability of familiar scents to trigger emotions and memories of times past, such as people in our lives, places we miss, or particular events, such as the holidays.

Who among us has not passed a restaurant or bakery and been immediately transported to another time when a similar dish or baked good was enjoyed, with all of its emotional accompaniments? Have we not all smelled a particular laundry detergent or perfume and thought of a loved family member or former flame? For some, even less-than-pleasant odors can call to mind a cherished memory. I have heard people say that walking into a faintly damp or musty house reminded them of the fun and friendships of summer camp, even 30 or more years later.

Today, the term aromatherapy refers to the deliberate use of plant-derived oils to enhance physical and emotional health. Although aromatherapy is still considered to lie outside the realm of medically accepted therapies and mainstream psychotherapy, interest in this area has grown substantially over the past few decades. Most of those who use aromas for healing tend to do so as part of a whole-person approach to healthcare, rather than as a stand-alone treatment. When applied thoughtfully, aromas may be incorporated into more “mainstream” healthcare practices with good results.

The Impact of Scents on Stress and Performance: What’s the Evidence?

Research related to the impact of scents, particularly essential oils, on mood has increased since the 1970s. Specifically, there have been several studies on the use of essential oils, such as lavender and rose, as well as other pleasant aromas to reduce stress. Lavender in particular has been shown to reduce self-reports of stress. In some preliminary research,  lavender was also linked to increased peripheral blood flow (an effect associated with relaxation) and a decrease in blood pressure, as well as positive changes in heart rate variability. In another trial, peppermint and lavender essential oils were associated with increased accuracy while proofreading.

The calming benefits of pleasant aromas many not be limited to essential oils, however. In at least two studies, the scent of coconut has been associated with decreased startle response, whereas an unpleasant scent (Limburger cheese) was associated with an increased startle response. A more recent study suggested that exposure to pleasant scent (also coconut) may blunt the body’s response to performing a stressful task and also enhance recovery after the stressor has stopped. It is important to note that most of these studies have had methodological challenges, including small numbers of people participating in the trials. Nonetheless, the results are thought-provoking and may make intuitive sense to those who have experienced subjective benefits from aromatherapy.

Aroma in Psychotherapy

How might this be relevant to the practice of psychotherapy? Pleasant aromas can be paired with relaxation training, such as diaphragmatic breathing, mindfulness practice, hypnotherapy, and biofeedback. Doing so may link the experience of relaxation with the scent sufficiently so that in the future, exposure to the scent alone may be enough to elicit the relaxation response.

In cognitive behavioral therapy, this pairing is referred to as “associative learning” or “higher-order conditioning,” and the goal is for the conditioned stimulus (the scent) to trigger the same response as the biofeedback, breathing, or meditation does.

I have frequently used scent as a therapeutic adjunct during all of the above types of treatments for both children and adults. Many have reported enjoying the use of this tool in session and on their own, eventually noticing that they can more quickly and effectively access a state of calm. Even something like at-home mindfulness practice involves “taking in” and being present with the scent of what one is consuming or doing. This includes experiencing fully the aromas associated with eating, drinking, or walking in nature. Thus, being mindfully present can be “aromatherapeutic” or at least “aroma-aware”—even without deliberately introducing a specific scent.

The at-home use of pleasant aroma can be as simple as adding a few drops of an essential oil to a hand or body lotion or hair conditioner, buying natural laundry or cleaning products that feature relaxing or invigorating essential oils, chewing a stick of peppermint gum while proofreading a term paper, or mindfully sipping a cup of fragrant tea.

Common Sense with Scents

When using scent in psychotherapy, it is important to take into account people’s individual preferences for and aversions to various aromas and be aware of the fact that some dislike using any scent at all. Similarly, it is important to inquire about emotional associations to scents that may be popular but could elicit unpleasant memories (“Ugh! My old boss always wore rose oil!”).

Finally, it goes without saying that one should:

1. Ask about allergies to any scents
2. Place undiluted oils on tissue or another object, rather than directly on the person, as many are harmful when applied to the skin at full strength
3. Educate oneself about the properties associated with different oils before introducing them into the work.

Additional Aromatherapy Resources

• For general information about aromatherapy, you can visit: www.aromaweb.com
• For information about training in clinical aromatherapy and the use of aromatherapy by health professionals, you can visit Dr. Jane Buckle’s website: http://www.rjbuckle.com/home.html or read her text, Clinical Aromatherapy: Essential Oils in Practice
• For a recent scientific article describing some of the studies mentioned here, see the text (available to journal subscribers and at many medical or nursing school libraries): Mezzacappa, E.S., Arumugam, U., Yue, S.I., Stein, T.R., Buckle, J., & Oz, M.C. (2010). Coconut fragrance and cardiovascular response to laboratory stress: Results of pilot testing. Holistic Nursing Practice, 24(5).